The Antidepressants WRECKING Your Heart (Must-See List)

It’s always shocked me how mainstream medicine hands out antidepressants like candy…

The truth is, doctors’ palms should be sweating every time they write a prescription.

We’re talking about a class of drugs that doesn’t work well for many people… and comes with a list of side effects a mile long.

We all know about the brain fog… the expanding waistlines… and the sex lives that get left in ruins by these drugs.

But there’s another problem that hasn’t been getting enough attention… until now.

Because research is showing that specific antidepressants could be putting you on the fast path to a heart attack or stroke.

And I’m going to name names, so don’t miss this.

New research in The Lancet, one of the leading medical journals in the world, looked at years of research on 30 commonly prescribed antidepressants.

Now, if you’re getting older, your doctor has probably talked to you about controlling your weight, blood pressure, and cholesterol if you want to avoid a heart attack or stroke.

Well, don’t expect any help from antidepressants.

Here are the exact drugs that have been linked to worsening health conditions that can significantly up your risk of heart disease or stroke:

Weight gain: Amitriptyline, fluvoxamine, maprotiline, mianserin, milnacipran, and mirtazapine.

Increased heart rate: Clomipramine, fluvoxamine, imipramin, and nortriptyline (this one was particularly bad).

Elevated blood pressure: Amitriptyline, doxepin, and maprotiline. 

Higher cholesterol: Desvenlafaxine, duloxetine, paroxetine, and venlafaxine.

The researchers found that antidepressants “differ markedly” in their effects on your cardiometabolic health, and called for treatment guidelines to be updated.

But don’t hold your breath waiting for that…

If you’re worried about your heart health – and especially if you have a history of heart disease – talk to your doctor if you’re taking any of the drugs on this list.

Better yet, ask your doctor if you still need to be on these meds in the first place.

Antidepressants were never meant to be a life sentence, and I’ve had a lot of success over the years helping patients taper off of these drugs.

It’s a slow process and you should never do it on your own – but it may be well worth discussing with your health care provider.

View Sources

Pillinger, T., Arumuham, A., McCutcheon, R. A., & Cipriani, A. (2025). The effects of antidepressants on cardiometabolic and other physiological parameters: A systematic review and network meta-analysis. The Lancet. https://doi.org/10.1016/S0140-6736(25)01293-0